Post-doctoral Fellow in Drug Delivery, Nanomedicine & Advanced Therapeutics

• Design and develop small molecules, nucleic acids and peptide therapeutics.
• Design, prepare and characterize nanoparticles.
• Employ state-of-the-art techniques to assess the physicochemical properties of nanoparticles, ensuring their stability, drug release kinetics, encapsulation efficiency and electron microscopy imaging.
• Integrate innovative approaches to enhance the specificity and efficiency of advanced therapeutics, with a particular emphasis on addressing challenges related to tissue penetration and targeted delivery.
• Conduct cell culture studies using cell lines, primary cultures and/or patients' tissues for efficacy evaluation.
• Conduct in vivo studies, including administration of nanoparticles, monitoring fate, therapeutic response, and assessing the impact on disease progression.
• Develop relevant disease models to assess therapeutic efficacy of a specific treatment.
• Demonstrate understanding of the disease pathology for better design of advanced therapeutics.
• Coordinate with clinical collaborators to obtain ethical approvals and obtaining human tissue samples for subsequent studies.
• Engage in collaborative projects both internally and externally.
• Periodically report progress to PI, co-investigators, project collaborators, and project funder.
• Initiate and contribute to grant writing activities.
• Write study-specific procedures for analytical methods, protocols, and reports and provide training on processes and equipment.
• Supervise and co-supervise undergraduate and postgraduate students.
• Disseminate research findings through the preparation of research articles and presentations at international conferences.
• Foster an agile and friendly working environment within the research group.

• Ph.D. in Pharmaceutical Sciences, Pharmacology, Biology, Molecular Biology, Biochemistry, Immunology, Bioengineering, Chemistry, Data Science or related fields.
• Post-doctorate experience preferred.
• Proven track record in conducting high-quality biological or chemical research.
• Demonstrated history of writing reports and scientific articles based on research results.

• Strong background in various research areas including pre-clinical studies, image-guided delivery, nucleic acid therapeutics, targeting and therapeutic aptamers/peptides, immunotherapy, RNA biology, nose-to-brain delivery, blood brain barrier targeting, nanoparticle formulation, peptide therapeutics, T cells therapy, extracellular vesicles, cancer vaccines, brain cancer, motor neuron disease, protein corona, hydrogels, and gene therapy/editing.
• Hands-on experience in advanced cell culture techniques and in vivo models.
• Proficiency in various cell and molecular biology experimentation techniques like PCR, gels, Western blotting, Immunohistochemistry, ELISA and flow cytometry, immune profiling.
• Experience in bioconjugations.

• Highly desirable skills include various in-vivo tracking modalities and imaging techniques for monitoring drug delivery dynamics.
• Additional advantageous skills involve working with patient tissue handling and culturing, surgical implantation of brain cancer, cryo-electron microscopy, transcriptome, proteome, single cell sequencing and bioinformatics, iPSC derived cells, tissue organoids and/or tissue slices, analytical techniques e.g. LC-MS, liquid scintillation, HPLC, MS, NMR.

• Ability to manage a research programme financially and administratively under the guidance of the Principal Investigator.
• Ability to work independently with excellent problem-solving skills, collaborate within a team, and supervise students.
• High attention to detail in experimental design and execution with a willingness to adapt to new procedures and undergo further training as necessary.

• Excellent command of written and spoken English.
• Capable of writing grants and contributing to additional funding acquisition.
• Proficient in IT skills for efficient data management and communication within the research programme.

Times Higher Education